Propuesta de un proceso para desarrollar productos de la ingeniería de tejidos por bioimpresión empleando baños de soporte tipo FRESH
DOI:
https://doi.org/10.54353/ritp.v3i2.e013Palavras-chave:
Productos médicos de la ingeniería de tejidos, Buenas Prácticas de Manufactura (BPM), Bioimpresión, Manufactura aditiva, Baños de soporte FRESHResumo
Introducción: La tecnología de la bioimpresión en tres dimensiones se está desarrollando con rapidez y, en consecuencia, existen publicaciones en diversas disciplinas que contribuyen al desarrollo científico y tecnológico de esta herramienta para la ingeniería de tejidos. Sobresale la técnica de impresión en baños de soporte FRESH, que permite la bioimpresión a microescala con alta integridad de forma que evita el colapso de las estructuras poco viscosas por efectos de la gravedad.
Objetivo: En este trabajo se busca sintetizar una serie de recomendaciones generadas a partir de la experiencia en el desarrollo de diferentes aplicaciones con énfasis en las Buenas Prácticas de Manufactura y el control de calidad necesarios para la fabricación de productos médicos de la ingeniería de tejidos. Se espera que estas recomendaciones faciliten la traslación de tecnologías propias de la ingeniería de tejidos para aplicaciones en el campo de la medicina regenerativa.
Métodos: El presente artículo revisa una serie de artículos y normas técnicas relevantes propuestos a partir de búsquedas sistemáticas estructuradas de procesos para desarrollar este tipo de productos. Se enfatizan los ensayos recurrentes para lograr este objetivo, desde el pretratamiento de los materiales hasta el post procesado previo al almacenamiento.
Resultados: Se ha generado una propuesta para incluir Buenas Prácticas de Manufactura de productos médicos mediante ingeniería de tejidos que usen la bioimpresión con baños de soporte tipo FRESH, de manera que pueda ser replicable a diferentes escalas de producción
Conclusiones: Las bondades de la manufactura aditiva empleando baños de soporte tipo FRESH se pueden trasladar y estandarizar fácilmente para la fabricación de productos médicos hechos por ingeniería de tejidos.
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Copyright (c) 2022 Lizardo Torres-Ayala, Fanny Lys Casado Peña
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